Recombinant Anti-IDH1 (mutated R132H) Antibody [IDH1/6806R] (A277999)

Anti-IDH1 (mutated R132H) Antibody [IDH1/6806R]

Recombinant rabbit monoclonal [IDH1/6806R] antibody to IDH1 (mutated R132H).

IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 281-414, of human IDH1 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

IDH1/6806R

IgG

kappa

Protein A/G chromatography.

200 µg/ml

45-47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IDH1 (mutated R132H) Antibody [IDH1/6806R] - BSA and Azide free (A278587).

Cytosolic NADP-isocitrate dehydrogenase, IDH, IDPc, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD