Anti-Human IgG4 Antibody [HP6025] (HRP) (A280648)

Anti-Human IgG4 Antibody [HP6025] (HRP)

Mouse monoclonal [HP6025] antibody to Human IgG4 (HRP).

This antibody recognises the heavy chain of human IgG4, at an epitope in the Fc region. No cross-reactivity is observed with IgG1, IgG2, IgG3, IgM, IgA. Elevated levels of IgG4 and of IgG4 presenting plasma cells are frequently seen in patients with autoimmune pancreatitis (IAP) and inflammatory bowel disease and it is suggested that IAP may develop as a paraneoplastic syndrome in some cancer patients

ELISA, IHC-Fr, IHC-P

ELISA: 1:1,000 - 1:20,000, IHC-Fr: 1:40 - 1:80

Human, Chimpanzee

Purified IgG4.

Mouse

Monoclonal

IgG1

Protein A affinity chromatography of ascites.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.01% Thiomersal.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human IgG4 antibody, clone HP6025 recognizes the heavy chain of human IgG4, at an epitope in the Fc region. No cross-reactivity is observed with IgG1, IgG2, IgG3, IgM, IgA (Jefferis et al. 1985).Elevated levels of IgG4 and of IgG4 presenting plasma cells are frequently seen in patients with autoimmune pancreatitis (IAP) and inflammatory bowel disease (Navaneethan et al. 2011) and it is suggested that IAP may develop as a paraneoplastic syndrome in some cancer patients (Shiokawa et al. 2013)

This product is for research use only. It is not intended for diagnostic or therapeutic use.