Anti-HSP90 alpha Antibody [HSP90AA1/7247] (A315115)

Anti-HSP90 alpha Antibody [HSP90AA1/7247]

Mouse monoclonal [HSP90AA1/7247] antibody to HSP90 alpha.

The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

Human spleen, stomach or pancreas tissue. MCF-7 cells.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 500-700) of human HSP90AA1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

90 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.