Anti-HSP60 Antibody [rGROEL/780] - BSA and Azide free
Description
Recombinant mouse monoclonal [rGROEL/780] antibody to HSP60.
Specificity
This antibody recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). Its epitope is localized between aa 383-447 of human hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsps). hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone rGROEL/780, unlike LK2, This antibody recognizes only the mammalian (not bacterial) hsp60 and is useful in distinguishing hsp60 from mammals and bacteria.
SDS-PAGE analysis of Anti-HSP60 Antibody [rGROEL/780] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Anti-HSP60 Antibody [rGROEL/780] - BSA and Azide free (A252069)
Analysis of protein array containing more than 19,000 full-length human proteins using Anti-HSP60 Antibody [rGROEL/780]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Publishing research using Recombinant Anti-HSP60 Antibody [rGROEL/780] - BSA and Azide free (A252069)? Please let us know so that we can list the citation on this page.
Alternative products to Anti-HSP60 Antibody [rGROEL/780] - BSA and Azide free (A252069)