Recombinant Anti-HSP60 Antibody [HSPD1/8398R] (A315102)

Anti-HSP60 Antibody [HSPD1/8398R]

Recombinant rabbit monoclonal [HSPD1/8398R] antibody to HSP60.

Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). Its epitope is localized between aa 383-447 of human hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsp s), more appropriately called as stress response proteins (srp s). hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone HSPD1/8398R, unlike LK2, recognizes only the mammalian (not bacterial) hsp60 and is useful in distinguishing hsp60 from mammals and bacteria.

HeLa or Hep2 cells. Synovial biopsies from patients with juvenile chronic arthritis. Synovial lining layer is strongly positive for hsp60. Breast carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant human full-length HSP60 protein.

Rabbit

Monoclonal

HSPD1/8398R

kappa

Protein A/G chromatography.

200 µg/ml

60 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

60 kDa chaperonin, 60 kDa heat shock protein, mitochondrial, Chaperonin 60, CPN60, Heat shock protein 60, Heat shock protein family D member 1, HSP-60, HSPD1, HuCHA60