Anti-HDAC1 Antibody [PCRP-HDAC1-1B7] (A277640)

Mouse monoclonal [PCRP-HDAC1-1B7] antibody to HDAC1 for ELISA, IP, Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-HDAC1 Antibody [PCRP-HDAC1-1B7]
Description
Mouse monoclonal [PCRP-HDAC1-1B7] antibody to HDAC1.
Specificity
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/ CBP-associated factor), p300/CBP and the TFIID subunit TAFII p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Applications
ELISA, IP, Flow Cytometry, IF
Dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human HDAC1 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-HDAC1-1B7
Isotype
IgG
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
60 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HDAC1 Antibody [PCRP-HDAC1-1B7] - BSA and Azide free (A278228).
Synonyms
HD1, HD10, HDAC10, Histone deacetylase 1, Histone deacetylase 10, Polyamine deacetylase HDAC10, Protein deacetylase HDAC1, Protein decrotonylase HDAC1, RPD3L1
Isotype Controls
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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