Recombinant Anti-Granzyme B Antibody [rGZMB/6740] (A277891)

Anti-Granzyme B Antibody [rGZMB/6740]

Recombinant mouse monoclonal [rGZMB/6740] antibody to Granzyme B.

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 73-187, of human Granzyme B protein. The exact sequence is proprietary.

Mouse

Monoclonal

rGZMB/6740

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

29-32 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Granzyme B Antibody [rGZMB/6740] - BSA and Azide free (A278479).

C11, Cathepsin G-like 1, CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, GRB, GZMB, Lymphocyte protease