Anti-Granzyme B Antibody [GB7] (A280505)

Anti-Granzyme B Antibody [GB7]

Mouse monoclonal [GB7] antibody to Granzyme B.

This antibody recognises the serine protease Granzyme B, expressed within the granules of cytolytic lymphocytes (CTLs)Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B activates the cascade of caspases that finally results in cell death. Mouse anti Human Granzyme B antibody, clone GB7 has been reported to be suitable for Western Blotting, demonstrating reactivity with recombinant granzyme B and also reactivity with recombinant granzyme H. Human granzymes B and H share ~71% sequence identity by clustal analysis.

IHC-P, WB

IHC-P 1: 1:50 - 1:200

Human

Recombinant Granzyme B.

Mouse

Monoclonal

GB7

IgG2a

1 mg/ml

Liquid

Supplied in TRIS Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Granzyme B antibody, clone GB7 recognizes the serine protease Granzyme B, expressed within the granules of cytolytic lymphocytes (CTLs)Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B activates the cascade of caspases that finally results in cell death.Mouse anti Human Granzyme B antibody, clone GB7 has been reported to be suitable for Western Blotting, demonstrating reactivity with recombinant granzyme B and also reactivity with recombinant granzyme H (Sedelies et al. 2004). Human granzymes B and H share ~71% sequence identity by clustal analysis.

C11, Cathepsin G-like 1, CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, GRB, GZMB, Lymphocyte protease