Anti-Glutamine Synthetase Antibody [GLUL/6604] (A277632)

Anti-Glutamine Synthetase Antibody [GLUL/6604]

Mouse monoclonal [GLUL/6604] antibody to Glutamine Synthetase.

Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 50-250, of human Glutamine Synthetase. The exact sequence is proprietary.

Mouse

Monoclonal

GLUL/6604

IgG2b

Protein A/G chromatography.

200 µg/ml

42 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Glutamine Synthetase Antibody [GLUL/6604] - BSA and Azide free (A278220).

GLNS, GLUL, Glutamate--ammonia ligase, GS, Palmitoyltransferase GLUL