Anti-Glutamine Synthetase Antibody [GLUL/6601] - BSA and Azide free (A316417)

Anti-Glutamine Synthetase Antibody [GLUL/6601] - BSA and Azide free

Mouse monoclonal [GLUL/6601] antibody to Glutamine Synthetase.

Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

WB, IHC-P

Human brain, stomach or thyroid. A-431 or Y79 cells.

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human, Horse, Canine, Feline

Recombinant fragment (around Amino Acids 50-250) of human GLUL protein. The exact sequence is proprietary.

Mouse

Monoclonal

GLUL/6601

kappa

Protein A/G chromatography.

1 mg/ml

42 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GLNS, GLUL, Glutamate--ammonia ligase, GS, Palmitoyltransferase GLUL