Recombinant Anti-GATA3 Antibody [GATA3/7686R] (A314992)

Anti-GATA3 Antibody [GATA3/7686R]

Recombinant rabbit monoclonal [GATA3/7686R] antibody to GATA3.

GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.

Human breast or urothelial carcinoma tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 150-250) of human GATA-3 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

GATA3/7686R

kappa

Protein A/G chromatography.

200 µg/ml

50 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GATA-binding factor 3, Trans-acting T-cell-specific transcription factor GATA-3