Anti-GAD67 Antibody [GAD1/2563] - BSA and Azide free (A251857)

Mouse monoclonal [GAD1/2563] antibody to GAD67 for ELISA, Flow Cytometry and WB.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-GAD67 Antibody [GAD1/2563] - BSA and Azide free
Description
Mouse monoclonal [GAD1/2563] antibody to GAD67.
Specificity
This antibody recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
Applications
ELISA, Flow Cytometry, WB
Dilutions
Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 72-135, of human GAD67 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
GAD1/2563
Isotype
IgG2b
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
67 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-GAD67 Antibody [GAD1/2563] (A248675).
Synonyms
67 kDa glutamic acid decarboxylase, GAD, GAD-67, Glutamate decarboxylase 1, Glutamate decarboxylase 67 kDa isoform
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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