Anti-GAD65 Antibody [GAD2/1960] (A248676)

Mouse monoclonal [GAD2/1960] antibody to GAD65 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-GAD65 Antibody [GAD2/1960]
Description
Mouse monoclonal [GAD2/1960] antibody to GAD65.
Specificity
This antibody recognizes a protein of 65kDa, which is identified as glutamic acid decarboxylase 2 (GDA2). It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD s) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67). GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 6-99, of human GAD65 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
GAD2/1960
Isotype
IgG2b
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
65 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-GAD65 Antibody [GAD2/1960] - BSA and Azide free (A251858).
Synonyms
65 kDa glutamic acid decarboxylase, GAD-65, GAD2, Glutamate decarboxylase 2, Glutamate decarboxylase 65 kDa isoform
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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