Recombinant Anti-FOXA1 Antibody [rFOXA1/1515] (A248860)

Anti-FOXA1 Antibody [rFOXA1/1515]

Recombinant mouse monoclonal [rFOXA1/1515] antibody to FOXA1.

The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors.HNF-1 (), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

Flow Cytometry, IHC-P

Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml

Human, Rat

Recombinant fragment, around amino acids 372-472, of human FOXA1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rFOXA1/1515

IgG1

Protein A/G chromatography.

200 µg/ml

49 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-FOXA1 Antibody [rFOXA1/1515] - BSA and Azide free (A252040).

Forkhead box protein A1, Hepatocyte nuclear factor 3-alpha, HNF-3-alpha, HNF-3A, HNF3A, TCF-3A, TCF3A, Transcription factor 3A