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Anti-FLI1 Antibody [FLI1/7508] - BSA and Azide free (A316355)

$790

Mouse monoclonal [FLI1/7508] antibody to FLI1 for WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.
Name
Anti-FLI1 Antibody [FLI1/7508] - BSA and Azide free
Description
Mouse monoclonal [FLI1/7508] antibody to FLI1.
Specificity
Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Applications
WB, IHC-P
Positive Control
THP1 and Raji cells. Tonsil, Ewing s sarcoma (EWS) and Angiosarcoma
Dilutions
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (aa 107-261) of human FLI1 protein with hexa-histidine tag.
Host
Mouse
Clonality
Monoclonal
Clone ID
FLI1/7508
Isotype
IgG2
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A chromatography.
Concentration
1 mg/ml
Molecular Weight
51 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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