Anti-Fibroblast Activation Protein alpha Antibody [FAP/4851] (A277594)

Mouse monoclonal [FAP/4851] antibody to Fibroblast Activation Protein alpha for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-Fibroblast Activation Protein alpha Antibody [FAP/4851]
Description
Mouse monoclonal [FAP/4851] antibody to Fibroblast Activation Protein alpha.
Specificity
FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 1-200, of human Fibroblast Activation Protein alpha. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
FAP/4851
Isotype
IgG2c
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
88 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4851] - BSA and Azide free (A278182).
Synonyms
170 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, FAPalpha, Gelatine degradation protease FAP, Integral membrane serine protease, Prolyl endopeptidase FAP
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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