Anti-Fas Ligand Antibody [FASLG/4453] - BSA and Azide free (A278255)

Mouse monoclonal [FASLG/4453] antibody to Fas Ligand for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-Fas Ligand Antibody [FASLG/4453] - BSA and Azide free
Description
Mouse monoclonal [FASLG/4453] antibody to Fas Ligand.
Specificity
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 107-222, of human Fas Ligand. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
FASLG/4453
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
26 kDa (soluble FAS-L) / 40 kDa (FAS-L membrane)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Fas Ligand Antibody [FASLG/4453] (A277667).
Synonyms
Apoptosis antigen ligand, APT1LG1, APTL, CD178, CD95 ligand, CD95-L, CD95L, Fas antigen ligand, FasL, FASLG, TNFSF6, Tumor necrosis factor ligand superfamily member 6
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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