Anti-Fas Antibody [LOB 3/17] (FITC) (A280890)

Anti-Fas Antibody [LOB 3/17] (FITC)

Mouse monoclonal [LOB 3/17] antibody to Fas (FITC).

This antibody recognises the human CD95 cell surface antigen, also known as Tumor necrosis factor receptor superfamily member 6, Fas, Apo-1 antigen, Apoptosis-mediating surface antigen FAS or FASLG receptor. CD95 is a 310 amino acid ~40-50 kDa single pass type I transmembrane glycoprotein expressed by activated T and B cells, NK cells and thymocytes. Mutations in the CD95 gene, FAS can lead to the development of Autoimmune lymphoproliferative syndrome 1A (ALPS1A), an apoptotic disorder with early onset resulting in an accumulation of autoreactive lymphocytes.

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human, Rhesus Monkey

Fusion protein comprising extracellular domain of human Fas linked to human Fc.

Mouse

Monoclonal

LOB 3/17

IgG1

Protein A affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CD95 antibody, clone LOB 3/17 recognizes the human CD95 cell surface antigen, also known as Tumor necrosis factor receptor superfamily member 6, Fas, Apo-1 antigen, Apoptosis-mediating surface antigen FAS or FASLG receptor. CD95 is a 310 amino acid ~40-50 kDa single pass type I transmembrane glycoprotein expressed by activated T and B cells, NK cells and thymocytes. Mutations in the CD95 gene, FAS can lead to the development of Autoimmune lymphoproliferative syndrome 1A (ALPS1A), an apoptotic disorder with early onset resulting in an accumulation of autoreactive lymphocytes (Peters et al. 1999).

Apo-1 antigen, Apoptosis-mediating surface antigen FAS, APT1, CD95, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6

This product is for research use only. It is not intended for diagnostic or therapeutic use.