Anti-Fas Antibody [E06-1A9] (A280290)

Anti-Fas Antibody [E06-1A9]

Mouse monoclonal [E06-1A9] antibody to Fas.

This antibody recognises CD95, also known as TNFRSF6, Apo-1 antigen, apoptosis-mediating surface antigen FAS and FASLG receptor. It is a member of the TNF receptor superfamily and is a death receptor. CD95 is a type I transmembrane glycoprotein which is ubiquitously expressed, but it is particularly abundant in the thymus, liver, heart and kidney tissues. Upon binding of its ligand CD95L, CD95 interacts with adaptor proteins to form a death-inducing signaling complex to trigger a cell death signal. However CD95 is also able to promote inflammation, normal and tumor cell growth and migration through other signaling pathways including PI3K, NF?B and JNK MAPKs. The purified Mouse anti Human CD95 antibody, clone E06-1A9 (MCA62672GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD95 antibody, clone C02-6C8 (MCA6273B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CD95 (Gln26-Val335).

Mouse

Monoclonal

E06-1A9

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD95 antibody, clone E06-1A9, recognizes CD95, also known as TNFRSF6, Apo-1 antigen, apoptosis-mediating surface antigen FAS and FASLG receptor. It is a member of the TNF receptor superfamily and is a death receptor. CD95 is a type I transmembrane glycoprotein which is ubiquitously expressed, but it is particularly abundant in the thymus, liver, heart and kidney tissues (Peter et al. 2015). Upon binding of its ligand CD95L, CD95 interacts with adaptor proteins to form a death-inducing signaling complex to trigger a cell death signal. However CD95 is also able to promote inflammation, normal and tumor cell growth and migration through other signaling pathways including PI3K, NF?B and JNK MAPKs (Levoin et al. 2020). The purified Mouse anti Human CD95 antibody, clone E06-1A9 (MCA62672GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD95 antibody, clone C02-6C8 (MCA6273B) as the detection antibody.

Apo-1 antigen, Apoptosis-mediating surface antigen FAS, APT1, CD95, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6