Recombinant Anti-Estrogen Receptor beta 1 Antibody [ESR2/7006R] (A277979)

Anti-Estrogen Receptor beta 1 Antibody [ESR2/7006R]

Recombinant rabbit monoclonal [ESR2/7006R] antibody to Estrogen Receptor beta 1.

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Flow Cytometry, IF, WB, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to the C terminus of human Estrogen Receptor beta protein.

Rabbit

Monoclonal

ESR2/7006R

kappa

Protein A/G chromatography.

200 µg/ml

53-59 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Estrogen Receptor beta 1 Antibody [ESR2/7006R] - BSA and Azide free (A278567).