Recombinant Anti-Estrogen Receptor alpha Antibody [ESR1/4039R] (A277976)

Anti-Estrogen Receptor alpha Antibody [ESR1/4039R]

Recombinant rabbit monoclonal [ESR1/4039R] antibody to Estrogen Receptor alpha.

This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to the C terminus of human Estrogen Receptor alpha.

Rabbit

Monoclonal

ESR1/4039R

IgG

kappa

Protein A/G chromatography.

200 µg/ml

~67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Estrogen Receptor alpha Antibody [ESR1/4039R] - BSA and Azide free (A278564).

ER, ER-alpha, ESR, ESR1, Estradiol receptor, Estrogen receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1