Recombinant Anti-ERG Antibody [rERG/6843] - BSA and Azide free (A278473)

Anti-ERG Antibody [rERG/6843] - BSA and Azide free

Recombinant mouse monoclonal [rERG/6843] antibody to ERG.

ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to the C terminus, around amino acids 450-479, of human ERG protein. The exact sequence is proprietary.

Mouse

Monoclonal

rERG/6843

IgG1

Protein A/G chromatography.

1 mg/ml

55 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-ERG Antibody [rERG/6843] (A277885).

Transcriptional regulator ERG, Transforming protein ERG