Anti-Endothelin B Receptor / ET-B Antibody (A282987)

Anti-Endothelin B Receptor / ET-B Antibody

Sheep polyclonal antibody to Endothelin B Receptor / ET-B.

This antibody recognises an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. recognises epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins. Sheep anti Rat endothelin B receptor antibody (AAR43) is suitable for use in immunocytochemistry on acetone fixed cells.

IHC-P, IF, IP, ICC

IF: 10 - 20 µg/ml, IHC-P: 10 - 20 µg/ml, IP: 20 - 40 µg/ml

Rat, Mouse, Human

Synthetic peptide sequence KANDHGYDNFRSSNN corresponding to amino acids 424-437 of the C-terminus of rat endothelin B receptor, conjugated to Keyhole Limpet Haemocyanin.

KANDHGYDNFRSSNN

Sheep

Polyclonal

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Sheep anti Rat endothelin B receptor antibody recognizes an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. Sheep anti Rat endothelin B receptor antibody (AAR43) recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins. Sheep anti Rat endothelin B receptor antibody (AAR43) is suitable for use in immunocytochemistry on acetone fixed cells.