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Anti-Endo G Antibody (A283913)

$435

Rabbit polyclonal antibody to Endo G for WB and IHC-P.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-Endo G Antibody
Description
Rabbit polyclonal antibody to Endo G.
Specificity
This antibody recognises human endonuclease G, also known as endoG. Endo G is a 297 amino acid, including a 48 amino acid transit peptide ~36 kDa mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.EndoG is reported to act independently of caspases and may represent a caspase independent apoptotic pathway initiated from the mitochondria.
Applications
WB, IHC-P
Dilutions
IHC-P 1: 15 µg/ml, WB: 1 µg/ml - 2 µg/ml
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide sequence GGPRGPGELAKYGLP corresponding to amino acids 55 - 70 of endonuclease G.
Sequence
GGPRGPGELAKYGLP
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Concentration
1 mg/ml
Molecular Weight
Approximately 35 kDa in HepG2 and 3T3 cell lysates.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Endonuclease G antibody recognizes human endonuclease G, also known as endoG. Endo G is a 297 amino acid, including a 48 amino acid transit peptide ~36 kDa mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.EndoG is reported to act independently of caspases and may represent a caspase independent apoptotic pathway initiated from the mitochondria (Li et al. 2001).
Synonyms
ENDOG, Endonuclease G, mitochondrial
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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