Anti-EGFR Antibody [GFR/1667] (A248407)

Anti-EGFR Antibody [GFR/1667]

Mouse monoclonal [GFR/1667] antibody to EGFR.

This antibody recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

WB, IHC-P

WB: 0.5-1.0 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant full-length human EGFR protein.

Mouse

Monoclonal

GFR/1667

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

~170 kDa (wild type) / ~145 kDa (vIII variant)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-EGFR Antibody [GFR/1667] - BSA and Azide free (A251589).

Epidermal growth factor receptor, ERBB, ERBB1, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1