Recombinant Anti-E Cadherin Antibody [rCDH1/7352] (A314900)

Anti-E Cadherin Antibody [rCDH1/7352]

Recombinant mouse monoclonal [rCDH1/7352] antibody to E Cadherin.

Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.

Human prostate or colon carcinomas.

IHC: 1-2 µg/ml

Human

Recombinant full-length human E-Cadherin protein.

Mouse

Monoclonal

rCDH1/7352

kappa

Protein A/G chromatography.

200 µg/ml

120-80 kDa (Mature) / 135 kDa (Precursor)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Cadherin-1, CAM 120/80, CD324, CDH1, CDHE, Epithelial cadherin, UVO, Uvomorulin