Anti-E Cadherin Antibody [CDH1/1525] - BSA and Azide free (A254005)

Mouse monoclonal [CDH1/1525] antibody to E Cadherin for Flow Cytometry, IF, WB and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-E Cadherin Antibody [CDH1/1525] - BSA and Azide free
Description
Mouse monoclonal [CDH1/1525] antibody to E Cadherin.
Specificity
This antibody recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- andP-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function.E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Applications
Flow Cytometry, IF, WB, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Cross Reactivity
This antibody does not cross react with Mouse or Rat.
Immunogen
Recombinant human E Cadherin protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
CDH1/1525
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
120-80 kDa (mature) / 135 kDa (Precursor)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-E Cadherin Antibody [CDH1/1525] (A250825).
Synonyms
Cadherin-1, CAM 120/80, CD324, CDH1, CDHE, Epithelial cadherin, UVO, Uvomorulin
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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