Anti-Dynorphin B Antibody (A283839)

Anti-Dynorphin B Antibody

Rabbit polyclonal antibody to Dynorphin B.

This antibody recognises dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, (YGGFLRRQFKVVT) derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B. The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009). Dynorphin b sequence is well conserved among mammal, avian and reptilian species. Rabbit anti Dynorphin b antibody is expected to have a wide species cross reactivity.

IHC-Fr, RIA

IHC-Fr: 1:250 - 1:2500, RadioIAs: 1:5,000

Porcine, Bovine, Chimpanzee, Dog, Gorilla, Horse, Human, Mouse, Rhesus Monkey, Hamster, Rat, Guinea Pig, Mouse

Synthetic peptide sequence YGGFLRRQFKVVT corresponding to full-length porcine dynorphin B (1-13), conjugated to thyroglobulin.

YGGFLRRQFKVVT

Rabbit

Polyclonal

IgG

Lot Specific

Serum.

Liquid

Supplied as serum with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Dynorphin B antibody recognizes dynorphin B, an endogenous opioid peptide, also known as rimorphin with the peptide sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr, (YGGFLRRQFKVVT) derived from the sequential cleavage of pro-enkephalin B to form leumorphin which is, in turn cleaved to form dynorphin B (Devi et al. 1985). The cleavage of the dynorphin precursors to form the dynorphin neuropeptides is largely controlled by the serine protease cathepsin L which co-localizes with dynorphins in secretory vesicles of brain cortical neurons (Funkelstein et al. 2010) and prohormone convertase 2, a member of the furin, peptidate S8 family (Schwarzer 2009). Dynorphin b sequence is well conserved among mammal, avian (Youngren et al. 1993) and reptilian (Goldsmith et al. 1992) species. Rabbit anti Dynorphin b antibody is expected to have a wide species cross reactivity.