Anti-DR5 Antibody (A283226)

Anti-DR5 Antibody

Goat polyclonal antibody to DR5.

This antibody recognises CD262, otherwise known as DR5/TRAIL-R2, a broadly expressed death domain containing receptor and member of the TNF-receptor superfamily, which acts as a mediator for CD253/TRAIL induced apoptosis in a variety of tumor and transformed cells, but not in normal cells. Expression of CD262 is regulated by tumor suppressor p53, and CD262 is highly expressed by tumor cell lines. The death domain containing adaptor protein FADD, is required for CD262-mediated apoptosis, and recruits caspase-8 to the activated receptor. Goat anti Human CD262 antibody is suitable for use in immunocytochemistry.

IHC-P, ELISA, Flow Cytometry

ELISA: 1:75,000, IHC-P: 1:150, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Human, Mouse

Synthetic peptide sequence APQQKRSSPSEGLCPPGHHISEDGRDC corresponding to amino acids 68-94 of the extracellular domain of human CD262.

APQQKRSSPSEGLCPPGHHISEDGRDC

Goat

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

CD262, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9