Anti-DNMT1 Antibody [DNMT1/2061] (A248346)

Anti-DNMT1 Antibody [DNMT1/2061]

Mouse monoclonal [DNMT1/2061] antibody to DNMT1.

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 767-912, of human DNMT1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

DNMT1/2061

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

184 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-DNMT1 Antibody [DNMT1/2061] - BSA and Azide free (A251528).

AIM, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, M.HsaI, MCMT