Anti-Desmoglein 3 Antibody [DSG3/1535] (A248375)

Anti-Desmoglein 3 Antibody [DSG3/1535]

Mouse monoclonal [DSG3/1535] antibody to Desmoglein 3.

This antibody recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment of extracellular human DSG3 protein.

Mouse

Monoclonal

DSG3/1535

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

130 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Desmoglein 3 Antibody [DSG3/1535] - BSA and Azide free (A251557).

130 kDa pemphigus vulgaris antigen, Cadherin family member 6, CDHF6, Desmoglein-3, DSG3, PVA