Anti-DC-SIGN Antibody [C209/6774] - BSA and Azide free (A278229)

Anti-DC-SIGN Antibody [C209/6774] - BSA and Azide free

Mouse monoclonal [C209/6774] antibody to DC-SIGN.

DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

Flow Cytometry: 0.5-1 µg/million cells

Human

Recombinant fragment corresponding to human CD209. The exact sequence is proprietary.

Mouse

Monoclonal

C209/6774

IgG1

Protein A/G chromatography.

1 mg/ml

45 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-DC-SIGN Antibody [C209/6774] (A277641).

C-type lectin domain family 4 member L, CD209, CD209 antigen, CLEC4L, DC-SIGN1, Dendritic cell-specific ICAM-3-grabbing non-integrin 1