Recombinant Anti-Cyclin E1 Antibody [rCCNE1/4936] (A277931)

Anti-Cyclin E1 Antibody [rCCNE1/4936]

Recombinant mouse monoclonal [rCCNE1/4936] antibody to Cyclin E1.

Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 10-176, of human Cyclin E1. The exact sequence is proprietary.

Mouse

Monoclonal

rCCNE1/4936

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

53 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Cyclin E1 Antibody [rCCNE1/4936] - BSA and Azide free (A278519).

CCNE, CCNE1, G1/S-specific cyclin-E1