Anti-Cyclin E1 Antibody (A283076)

Anti-Cyclin E1 Antibody

Rabbit polyclonal antibody to Cyclin E1.

This antibody recognises cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary.Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication.Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia.

WB, ELISA, IP

ELISA: 1:2,000, IP: 1:100, WB: 1:2,000 - 1:10 000

Human, Mouse, Rat

Synthetic peptide corresponding to a region near the C-terminus of human Cyclin E conjugated to Keyhole Limpet Haemocyanin.

Rabbit

Polyclonal

IgG

Approximately 45 kDa in from human, rat and mouse tissue.

Serum.

Liquid

Supplied as serum with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human Cyclin E antibody detects cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary. Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication. Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia.

CCNE, CCNE1, G1/S-specific cyclin-E1