Anti-Cyclin D1 Antibody [SPM587] (PE) (A251192)

Anti-Cyclin D1 Antibody [SPM587] (PE)

Mouse monoclonal [SPM587] antibody to Cyclin D1 (PE).

This antibody recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Flow Cytometry, IF

Flow Cytometry: 5-10 µl / million cells, IF: 1:50-1:100

Human, Monkey, Mouse, Rat

Recombinant full-length human Cyclin D1 protein.

Mouse

Monoclonal

SPM587

kappa

Protein A/G chromatography.

100 µg/ml

36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Store at 4-8°C. Antibody is stable for 24 months.

B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1, CCND1, G1/S-specific cyclin-D1, PRAD1, PRAD1 oncogene

This product is for research use only. It is not intended for diagnostic or therapeutic use.