Anti-Cyclin D1 Antibody [CCND1/7868] (A314833)

Anti-Cyclin D1 Antibody [CCND1/7868]

Mouse monoclonal [CCND1/7868] antibody to Cyclin D1.

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Human mantle cell lymphoma, breast or bladder carcinomas.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-295) of Cyclin D1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

CCND1/7868

IgG2a

Protein A/G chromatography.

200 µg/ml

36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1, CCND1, G1/S-specific cyclin-D1, PRAD1, PRAD1 oncogene