Anti-Cyclin D1 Antibody [CCND1/3370R] - BSA and Azide free (A253041)

Anti-Cyclin D1 Antibody [CCND1/3370R] - BSA and Azide free

Rabbit monoclonal [CCND1/3370R] antibody to Cyclin D1.

This antibody recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

IHC-P: 1-2 µg/ml

Human

Synthetic peptide, within amino acids 270-295, of Cyclin D1. The exact sequence is proprietary.

Rabbit

Monoclonal

CCND1/3370R

IgG

Protein A/G chromatography.

1 mg/ml

36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Cyclin D1 Antibody [CCND1/3370R] (A249861).

B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1, CCND1, G1/S-specific cyclin-D1, PRAD1, PRAD1 oncogene