Anti-CXCR4 Antibody (A283228)

Anti-CXCR4 Antibody

Goat polyclonal antibody to CXCR4.

This antibody recognises an epitope within the N-terminal region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Goat anti Human CD184 / CXCR4 antibody is being suitable for use in immunofluorescence.

WB, IHC-P, ELISA

ELISA: 1:25,000, IHC-P: 1:150, WB: 1:250

Human, Rat

Synthetic peptide sequence TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-terminus of human CD184 / CXCR4.

TEEMGSGDYDSMKEPCFREENANFNKC

Goat

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Goat anti Human CD184 / CXCR4 antibody recognizes an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. Goat anti Human CD184 / CXCR4 antibody is being suitable for use in immunofluorescence.

C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor