Anti-CXCR4 Antibody (A282962)

Anti-CXCR4 Antibody

Goat polyclonal antibody to CXCR4.

This antibody recognises an epitope within the N-terminal region of mouse CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1).Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates.This antibody is reported as being suitable for use in immunocytochemistry on mouse spleen leucocytes.

WB, IHC-P, ELISA

ELISA: 1:50,000, IHC-P: 1:300, WB: 1:1,000

Mouse, Xenopus

Synthetic peptide sequence YSEEVGSGDYDSNKEPCFRDENVHFNR corresponding to amino acids 14-40 within the N-terminus of mouse CD184 / CXCR4.

YSEEVGSGDYDSNKEPCFRDENVHFNR

Goat

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Goat anti Mouse CD184 / CXCR4 recognises an epitope within the N-terminal (NT) region of mouse CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1).Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates.This antibody is reported as being suitable for use in immunocytochemistry on mouse spleen leucocytes.

C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor