Anti-CXCR4 Antibody [9D9] (A279571)

$355

Mouse monoclonal [9D9] antibody to CXCR4 for IF, Flow Cytometry and IHC-Fr.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-CXCR4 Antibody [9D9]
Description
Mouse monoclonal [9D9] antibody to CXCR4.
Specificity
This antibody recognises the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.Bursa cells may be used as a positive control for CXCR4 in flow cytometry.
Applications
IF, Flow Cytometry, IHC-Fr
Dilutions
Use 10µl of the suggested working dilution to label 1x106 cells in 100µl
Reactivity
Chicken
Immunogen
Chicken CXCR4 (chCXCR4) transfected HEK294 cells.
Host
Mouse
Clonality
Monoclonal
Clone ID
9D9
Isotype
IgG2a
Conjugate

Unconjugated

Purification
Protein G affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Chicken CD184 / CXCR4 clone 9D9, recognizes the chicken homologue of human CD184, also known as CXCR4 (C-X-C Receptor type 4) and fusin.CXCR4 is a receptor for the chemokine, stromal-derived factor-1 (SDF-1), also known as CXCL12. Research has demonstrated that in chicks CXCR4 is expressed by cardiac neural crest cells and together with SDF-1 is involved with the migration of cells and development of the heart. Where CXCR4 function is lost, cell migration is impaired resulting in cell death and misexpression of SDF-1 leading to cardiovascular defects (Escot et al. 2013). CXCR4 expression is also linked with other development processes including cerebellar development and with vascularization of the gastrointestinal tract. Clone 9D9 provides a useful antibody for studying development biological processes.Bursa cells may be used as a positive control for CXCR4 in flow cytometry.
Synonyms
C-X-C chemokine receptor type 4, CD184, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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