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Anti-Collagen I Antibody [NFI/20] (A281318)

$350

Mouse monoclonal [NFI/20] antibody to Collagen I for ELISA and IHC-Fr.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-Collagen I Antibody [NFI/20]
Description
Mouse monoclonal [NFI/20] antibody to Collagen I.
Specificity
This antibody recognises human Collagen I composed of trimers consisting of 2 Collagen alpha-2(I) chains and a single Collagen alpha-1(I) chain forming collagen fibrils in ligaments, tendon, skin and bone where they become mineralized by calcium hydroxyapatite. Mouse anti human Collagen I, clone NFI/20 does not cross-react with collagen types II, III and IV. Collagen is located in the extracellular matrix of connective tissues. It is part of the interacting network of proteoglycans and proteins that provides a structural framework for both soft and calcified connective tissues.Mutations in the encoding gene are associated with osteogenesis imperfecta , Ehlers Danlos syndrome and idiopathic juvenile osteoporosis. Defective processing of collagen I by lysyl hydroxylase has also been implicated in Ehlers Danlos syndrome ,
Applications
ELISA, IHC-Fr
Dilutions
ELISA: 1:1,000, IHC-Fr: 1:20
Reactivity
Human
Immunogen
Human Collagen type I from placenta.
Host
Mouse
Clonality
Monoclonal
Clone ID
NFI/20
Isotype
IgG1
Conjugate

Unconjugated

Purification
Ammonium sulphate precipitation and DEAE-cellulose chromatography of ascites.
Concentration
Reconstitution dependent.
Product Form
Lyophilized
Reconstitution
Reconstitute with 1 ml of sterile distilled water.
Formulation
Supplied in 0.1M Sodium Chloride with 0.01M Sodium Phosphate, 0.01M Sodium Borate, 1% Dextran, and 1% Mannitol.
Storage
Lyophilized: Store at 4°C. Reconstituted: Store at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human Collagen I, clone NFI/20 recognizes human Collagen I composed of trimers consisting of 2 Collagen alpha-2(I) chains and a single Collagen alpha-1(I) chain forming collagen fibrils in ligaments, tendon, skin and bone where they become mineralized by calcium hydroxyapatite. Mouse anti human Collagen I, clone NFI/20 does not cross-react with collagen types II, III and IV. Collagen is located in the extracellular matrix of connective tissues. It is part of the interacting network of proteoglycans and proteins that provides a structural framework for both soft and calcified connective tissues.Mutations in the encoding gene are associated with osteogenesis imperfecta (Peng et al. 2012), Ehlers Danlos syndrome (Nuytinck et al. 2000) and idiopathic juvenile osteoporosis (Pocock et al. 1995). Defective processing of collagen I by lysyl hydroxylase has also been implicated in Ehlers Danlos syndrome (Ihme et al. 1984),
Synonyms
Alpha-1 type I collagen, COL1A1, Collagen alpha-1(I) chain
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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