General Notes
Collagen is located in the extracellular matrix of connective tissues. It is part of the interacting network of proteoglycans and proteins that provides a structural framework for both soft and calcified connective tissues. Type I collagen (~95 kDa) is found in bone, cornea, skin and tendon.Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. The use of Rabbit anti Rat Collagen I antibody in western Blotting is not currently supported, however, it has been reported that this antibody has been used successfully for the quantitation of collagen I in rabbit aortic tissue by western blotting.