Anti-Clusterin Antibody (A282999)

Anti-Clusterin Antibody

Rabbit polyclonal antibody to Clusterin.

This antibody recognises human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms; a proapoptotic nuclear form, of ~49 kDa, and a prosurvival secretory form with a molecular mass of 75-80 kDa. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis.Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumours.Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. Clusterin upregulated in Alzheimer’s disease , retinitis pigmentosa (Jomary et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction.

WB, IHC-P

WB: 0.5 - 1 µg/ml

Human

Recombinant human clusterin isoform 1.

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human clusterin antibody recognizes human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms; a proapoptotic nuclear form, of ~49 kDa, and a prosurvival secretory form with a molecular mass of 75-80 kDa. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis.Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumours.Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. Clusterin upregulated in Alzheimer’s disease (Miners et al. 2017), retinitis pigmentosa (Jomary et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction (Rosenberg et al. 2002).

Aging-associated gene 4 protein, Apo-J, APOJ, Apolipoprotein J, CLI, CLU, Complement cytolysis inhibitor, Complement-associated protein SP-40,40, Ku70-binding protein 1, KUB1