Recombinant Anti-CFTR Antibody [rCFTR/8047] (A314783)

Anti-CFTR Antibody [rCFTR/8047]

Recombinant mouse monoclonal [rCFTR/8047] antibody to CFTR.

Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Human pancreas, kidney or placenta.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 550-850) of human CFTR protein. The exact sequence is proprietary.

Mouse

Monoclonal

rCFTR/8047

kappa

Protein A/G chromatography.

200 µg/ml

165-170 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ABCC7, ATP-binding cassette sub-family C member 7, cAMP-dependent chloride channel, Channel conductance-controlling ATPase, Cystic fibrosis transmembrane conductance regulator, EC:5.6.1.6