Recombinant Anti-CDK4 Antibody [CDK4/7987R] (A314769)

Anti-CDK4 Antibody [CDK4/7987R]

Recombinant rabbit monoclonal [CDK4/7987R] antibody to CDK4.

Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth (PMID:21844184). CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas, but rarely expressed in other benign liposarcomas and other sarcomas. CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+), dedifferentiated liposarcoma (+) and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma and other high-grade sarcomas.

Human urothelial carcinoma, cervical carcinoma and liposarcomas.

IHC: 1-2 µg/ml

Human

Recombinant fragment corresponding to N-terminal of human CDK4 protein.

Rabbit

Monoclonal

CDK4/7987R

kappa

Protein A/G chromatography.

200 µg/ml

34 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3