Anti-CD98 Antibody [H202-529.4.1.4] (A280542)

Anti-CD98 Antibody [H202-529.4.1.4]

Rat monoclonal [H202-529.4.1.4] antibody to CD98.

This antibody recognises mouse CD98, also known as 4F2 and SLC3A2. CD98 is a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis.

Flow Cytometry: Neat for 0.25 mg, 1:20 for 0.1 mg - 1:50 for 0.25 mg, 1:200 for 0.1 mg, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Mouse

Thymic epithelial cells from mouse.

Rat

Monoclonal

H202-529.4.1.4

IgG1

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Mouse CD98 antibody, clone H202-529.4.1.4 recognizes murine CD98, also known as 4F2 and SLC3A2. CD98 is a type II transmembrane glycoprotein which associates with members of the L-type amino transporter family to form a heterodimeric complex.CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis (Cantor & Ginsberg 2012).

4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, 4F2hc, Amino acid transporter heavy chain SLC3A2, Lymphocyte activation antigen 4F2 large subunit, MDU1, SLC3A2, Solute carrier family 3 member 2