Anti-CD8A Antibody [7C2B] (A279517)

Anti-CD8A Antibody [7C2B]

Mouse monoclonal [7C2B] antibody to CD8A.

This antibody recognises bovine CD8a. CD8a is a coreceptor for MHC I molecules. It is involved in the activation of the cytotoxic T-cell response and the clearance of virally infected cells. CD8 is predominantly present either as homodimer or a multimer of the alpha chain or as heterodimer of the alpha and beta chains. Bovine CD8 differs from the CD8 molecules of other animal species and shares 57.85% identity with swine, 37.70% with recognises bovine CD8 lymphocytes and gamma delta CD8+ lymphocytes. In addition it reacts with the CD8 lymphocytes of water buffalo.

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Bovine, Goat, Sheep, Bison, Water Buffalo

Mouse

Monoclonal

7C2B

IgG2a

0.2µM sterile filtered.

Liquid

Supplied in serum free tissue culture medium containing proprietary protein free supplement and 0.09% Sodium Azide.

Store at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Bovine CD8a, clone 7C2B, recognizes bovine CD8a. CD8a is a coreceptor for MHC I molecules. It is involved in the activation of the cytotoxic T-cell response and the clearance of virally infected cells. CD8 is predominantly present either as homodimer or a multimer of the alpha chain or as heterodimer of the alpha and beta chains (Littman et al. 1987). Bovine CD8 differs from the CD8 molecules of other animal species and shares 57.85% identity with swine, 37.70% with mouse, 27.50 % with chicken, and 20.69% identity with carp (Zhenbao et al. 2014).Mouse anti Bovine CD8a, clone 7C2B recognizes bovine CD8 lymphocytes and gamma delta CD8+ lymphocytes (Park et al. 2000). In addition it reacts with the CD8 lymphocytes of water buffalo (Davis et al. 2001).

MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2