Recombinant Anti-CD86 Antibody [rC86/6872] - BSA and Azide free (A278523)

Anti-CD86 Antibody [rC86/6872] - BSA and Azide free

Recombinant mouse monoclonal [rC86/6872] antibody to CD86.

This antibody recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 66-195, of human CD86 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rC86/6872

IgG1

Protein A/G chromatography.

1 mg/ml

70 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD86 Antibody [rC86/6872] (A277935).

Activation B7-2 antigen, B70, BU63, CD28LG2, CTLA-4 counter-receptor B7.2, FUN-1, T-lymphocyte activation antigen CD86