Recombinant Anti-CD74 Antibody [rCLIP/8679] (A314743)

Anti-CD74 Antibody [rCLIP/8679]

Recombinant mouse monoclonal [rCLIP/8679] antibody to CD74.

It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Human tonsil or lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human CD74 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rCLIP/8679

kappa

Protein A/G chromatography.

200 µg/ml

33-41 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DHLAG, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii