Anti-CD68 Antibody [Ki-M7] (FITC) (A280818)

Anti-CD68 Antibody [Ki-M7] (FITC)

Mouse monoclonal [Ki-M7] antibody to CD68 (FITC).

This antibody recognises human CD68 an integral membrane glycoprotein of ~110 kDa also known as Macrosialin or Gp110. CD68 is predominantly expressed on the intracellular lysosomes of macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including Acute Myeloid Leukemia. In immunohistochemistry, CD68 can be used to aid in the identification of blastic NK lymphomas, some B cell lymphomas, and to help diagnose disorders relating to macrophage abnormalities, including malignant histocytosis and Gaucher’s disease. Clone Ki-M7 has also been reported as being suitable for use in immunoprecipitation.

Use 20µl of the suggested working dilution to label 10⁶ cells in 100µl

Human, African green monkey

Human lymph node tissue.

Mouse

Monoclonal

Ki-M7

IgG1

Protein A affinity chromatography of tissue culture supernatant.

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 0.05% Sodium Azide and 1% BSA.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD68 antibody, clone Ki-M7 recognizes human CD68 an integral membrane glycoprotein of ~110 kDa also known as Macrosialin or Gp110. CD68 is predominantly expressed on the intracellular lysosomes of macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including Acute Myeloid Leukemia. In immunohistochemistry, CD68 can be used to aid in the identification of blastic NK lymphomas, some B cell lymphomas, and to help diagnose disorders relating to macrophage abnormalities, including malignant histocytosis and Gaucher’s disease. Clone Ki-M7 has also been reported as being suitable for use in immunoprecipitation.

Gp110, Macrosialin

This product is for research use only. It is not intended for diagnostic or therapeutic use.